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Publications

Huycke TR, Miller BM, Gill HK, Nerurkar NL, Sprinzak D, Mahadevan L, Tabin CJ.

Genetic and Mechanical Regulation of Intestinal Smooth Muscle Development.

Cell. 2019 Sep 19;179(1):90-105.e21. doi: 10.1016/j.cell.2019.08.041.

Asaf Liberman, Matan Mussel, Danny Kario, David Sprinzak, Uri Nevo

Modelling cell surface dynamics and cell-cell interactions using Cell Studio: a three-dimensional visualization tool based on gaming technology

J R Soc Interface 2019 Nov 29;16(160):20190264. doi: 10.1098/rsif.2019.0264

D. Sprinzak, A. Lakhanpal, L. LeBon, L. A. Santat, M. E. Fontes, G. A. Anderson, J. Garcia-Ojalvo, M. B. Elowitz.
Cis interactions between Notch and Delta generate mutually exclusive signaling states

Nature. 2010 May 6;465(7294):86-90. doi: 10.1038/nature08959.

D. Sprinzak, A. Lakhanpal, L. LeBon, J. Garcia-Ojalvo, M. B. Elowitz.
Mutual inactivation of Notch receptors and ligands facilitates developmental patterning

PLoS Comput Biol. 2011 Jun;7(6):e1002069. doi: 10.1371/journal.pcbi.1002069

O. Shaya, D. Sprinzak.
From Notch signaling to fine-grained patterning: Modeling meets experiments.

Curr Opin Genet Dev. 2011 Dec;21(6):732-9. doi: 10.1016/j.gde.2011.07.007

A. Yaron, D. Sprinzak.
The cis side of juxtacrine signaling: a new role in the development of the nervous system.
Trends Neurosci. 2012 Apr;35(4):230-9. doi: 10.1016/j.tins.2011.12.003

Formosa-Jordan P, Sprinzak D.
Modeling Notch signaling: a practical tutorial.
Methods Mol Biol. 2014;1187:285-310. doi: 10.1007/978-1-4939-1139-4_22.

Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S, Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau M, Kanaan M, Chen P, Matsuzaki F, Sprinzak D, Avraham KB.
The GPSM2/LGN GoLoco motifs are essential for hearing

Mamm Genome. 2016 Feb;27(1-2):29-46. doi: 10.1007/s00335-015-9614-7

Jones C, Qian D, Kim SM, Li S, Ren D, Knapp L, Sprinzak D, Avraham KB, Matsuzaki F, Chi F, Chen P.
Ankrd6 is a mammalian functional homolog of Drosophila planar cell polarity gene diego and regulates coordinated cellular orientation in the mouse inner ear.

Dev Biol. 2014 Sep 10. pii: S0012-1606(14)00420-5. doi: 10.1016/j.ydbio.2014.08.029.

LeBon L, Lee TV, Jafar-Nejad H, Sprinzak D, Elowitz MB.
Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states.

Elife. 2014 Sep 25;3. doi: 10.7554/eLife.02950.

Yaron T., Cordova Y., Sprinzak D.
Juxtacrine Signaling Is Inherently Noisy.

Biophys J. 2014 Nov 18;107(10):2417-24. doi: 10.1016/j.bpj.2014.10.006.

Golan T, Messer AR, Amitai-Lange A, Melamed Z, Ohana R, Bell RE, Kapitansky O, Lerman G, Greenberger S, Khaled M, Amar N, Albrengues J, Gaggioli C, Gonen P, Tabach Y,Sprinzak D, Shalom-Feuerstein R, Levy C..
Interactions of Melanoma Cells with Distal Keratinocytes Trigger Metastasis via Notch Signaling Inhibition of MITF

Mol Cell. 2015 Aug 20;59(4):664-76. doi: 10.1016/j.molcel.2015.06.028

Bhonker Y, Abu-Rayyan A, Ushakov K, Amir-Zilberstein L, Shivatzki S, Yizhar-Barnea O, Elkan-Miller T, Tayeb-Fligelman E, Kim SM, Landau M, Kanaan M, Chen P, Matsuzaki F, Sprinzak D, Avraham KB.
The GPSM2/LGN GoLoco motifs are essential for hearing

Mamm Genome. 2016 Feb;27(1-2):29-46. doi: 10.1007/s00335-015-9614-7

Khait I, Orsher Y, Golan O, Binshtok U, Gordon-Bar N, Amir-Zilberstein L, Sprinzak D.
Quantitative Analysis of Delta-like 1 Membrane Dynamics Elucidates the Role of Contact Geometry on Notch Signaling

Cell Rep. 2016 Jan 12;14(2):225-33. doi: 10.1016/j.celrep.2015.12.040

Wieland E, Rodriguez-Vita J, Liebler SS, Mogler C, Moll I, Herberich SE, Espinet E, Herpel E, Menuchin A, Chang-Claude J, Hoffmeister M, Gebhardt C, Brenner H, Trumpp A, Siebel CW, Hecker M, Utikal J, Sprinzak D, Fischer A.
Endothelial Notch1 Activity Facilitates Metastasis

Cancer Cell. 2017 Mar 13;31(3):355-367. doi: 10.1016/j.ccell.2017.01.007

Shaya O, Binshtok U, Hersch M, Rivkin D, Weinreb S, Amir-Zilberstein L, Khamaisi B, Oppenheim O, Desai RA, Goodyear RJ, Richardson GP, Chen CS, Sprinzak D.
Cell-Cell Contact Area Affects Notch Signaling and Notch-Dependent Patterning.

Dev Cell. 2017 Mar 13;40(5):505-511.e6. doi: 10.1016/j.devcel.2017.02.009.

Kovall RA, Gebelein B, Sprinzak D, Kopan R.
The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force.

Dev Cell. 2017 May 8;41(3):228-241. doi: 10.1016/j.devcel.2017.04.001.

Loza O, Heemskerk I, Gordon-Bar N, Amir-Zilberstein L, Jung Y, Sprinzak D.
A Synthetic Planar Cell Polarity System Reveals Localized Feedback on Fat4-Ds1 Complexes. 

Elife. 2017 Aug 18;6:e24820. doi: 10.7554/eLife.24820.

Shilo BZ, Sprinzak D.
The lipid-binding side of Notch ligands.
EMBO J. 2017 Aug 1; 36(15):2182-2183. doi: 10.15252/embj.201797621. Epub 2017 Jul 14.

Nandagopal N, Santat LA, LeBon L, Sprinzak D, Bronner ME, Elowitz MB.
Dynamic Ligand Discrimination in the Notch Signaling Pathway.  
Cell. 2018 Feb 8; 172(4):869-880.e19. doi: 10.1016/j.cell.2018.01.002. Epub 2018 Feb 1.

Tetzlaff F, Adam MG, Feldner A, Moll I, Menuchin A, Rodriguez-Vita J, Sprinzak D, Fischer A.
MPDZ promotes DLL4-induced Notch signaling during angiogenesis.  
Elife. 2018 Apr 5; 7. pii: e32860. doi: 10.7554/eLife.32860.

Binshtok U, Sprinzak D.
The Domino Effect in EGFR-ERK Signaling.
Dev Cell. 2018 Jul 16;46(2):128-130. doi: 10.1016/j.devcel.2018.06.021.

Binshtok U, Sprinzak D.
Modeling the Notch Response.
Adv Exp Med Biol. 2018;1066:79-98. doi: 10.1007/978-3-319-89512-3_5. Review.

Liubomirski Y, Lerrer S, Meshel T, Morein D, Rubinstein-Achiasaf L, Sprinzak D, Wiemann S, Körner C, Ehrlich M, Ben-Baruch A.
Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer. 
Front Immunol. 2019 Apr 24;10:804. doi: 10.3389/fimmu.2019.00804. eCollection 2019.

Pierre François Lenne, Ed Munro, Idse Heemskerk, Aryeh Warmflash, Laura Bocanegra-Moreno, Kasumi Kishi, Anna Kicheva, Yuchen Long, Antoine Fruleux, Arezki Boudaoud, Timothy E Saunders, Paolo Caldarelli, Arthur Michaut, Jerome Gros, Yonit Maroudas-Sacks, Kinneret Keren, Edouard Hannezo, Zev J Gartner, Benjamin Stormo Stormo, Amy Gladfelter Gladfelter, Alan Rodrigues, Amy Shyer, Nicolas Minc, Jean-Léon Maître, Stefano Di Talia, Bassma Khamaisi, David Sprinzak, Sham Tlili

Roadmap on multiscale coupling of biochemical and mechanical signals during development. 

Phys Biol. 2020 Dec 4. doi: 10.1088/1478-3975/abd0db

Francis M Kobia, Kristina Preusse, Quanhui Dai, Nicholas Weaver, Matthew R Hass, Praneet Chaturvedi, Sarah J Stein, Warren S Pear, Zhenyu Yuan, Rhett A Kovall, Yi Kuang, Natanel Eafergen, David Sprinzak, Brian Gebelein, Eric W Brunskill, Raphael Kopan

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation. 

PLoS Biol. 2020 Oct 5;18(10):e3000850. doi: 10.1371/journal.pbio.3000850

Yi Kuang, Ohad Golan, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak, Brian Gebelein

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism. 

Elife. 2020 Apr 16;9:e53659. doi: 10.7554/eLife.53659.

Cristina Porcheri, Ohad Golan, Fernando J Calero-Nieto, Roshana Thambyrajah, Cristina Ruiz-Herguido, Xiaonan Wang, Francesca Catto, Yolanda Guillén, Roshani Sinha, Jessica González, Sarah J Kinston, Samanta A Mariani, Antonio Maglitto, Chris S Vink, Elaine Dzierzak, Pierre Charbord, Bertie Göttgens, Lluis Espinosa, David Sprinzak, Anna Bigas

Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

EMBO J. 2020 Apr 15;39(8):e104270. doi: 10.15252/embj.2019104270.

Cohen R, Amir-Zilberstein L, Hersch M, Woland S, Loza O, Taiber S, Matsuzaki F, Bergmann S, Avraham KB, Sprinzak D.

Mechanical forces drive ordered patterning of hair cells in the mammalian inner ear. 

Nat Commun 11, 5137 (2020). https://doi.org/10.1038/s41467-020-18894-8

Shahar Taiber, Roie Cohen, Ofer Yizhar-Barnea, David Sprinzak, Jeffrey R Holt, Karen B Avraham

Neonatal AAV gene therapy rescues hearing in a mouse model of SYNE4 deafness. 

EMBO Mol Med. 2021 Feb 5;13(2):e13259. doi: 10.15252/emmm.202013259.

D. Sprinzak and M. Elowitz.
Reconstruction of genetic circuits

Nature. 2005 Nov 24;438(7067):443-8. doi: 10.1038/nature04335.

David Sprinzak, Stephen C Blacklow

Biophysics of Notch Signaling

Annu Rev Biophys. 2021 Feb 3. doi: 10.1146/annurev-biophys-101920-082204.

S. Thiberge, A. Nechushtan, D. Sprinzak, O. Gileadi, V. Behar, O. Zik, Y. Chowers, S. Michaeli, J. Schlessinger, E. Moses.
Scanning electron microscopy of cells and tissues under fully hydrated conditions

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3346-51. doi: 10.1073/pnas.0400088101

Yi Kuang, Anna Pyo, Natanel Eafergan, Brittany Cain, Lisa M. Gutzwiller, Ofri Axelrod, Ellen K. Gagliani, Matthew T. Weirauch, Raphael Kopan, Rhett A. Kovall, David Sprinzak, Brian Gebelein

Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor

bioRxiv 2020.07.12.199422; doi: https://doi.org/10.1101/2020.07.12.199422

Nicolas Dray, Laure Mancini, Udi Binshtok, Felix Cheysson, Willy Supatto, Pierre Mahou, Sébastien Bedu, Sara Ortica, Monika Krecsmarik, Sébastien Herbert, Jean-Baptiste Masson, Jean-Yves Tinevez, Gabriel Lang, Emmanuel Beaurepaire, David Sprinzak, Laure Bally-Cuif

Dynamic spatiotemporal coordination of neural stem cell fate decisions through local feedback in the adult vertebrate brain

bioRxiv 2020.07.15.205021; doi: https://doi.org/10.1101/2020.07.15.205021

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